The U.S. government estimates that only 12% of Americans have proficient health literacy and 35% (~77 million people) are at a basic or below basic level of health literacy. These statistics disproportionately affect those with public health insurance or uninsured, racial/ethnic minorities, or lower education levels. [1] This presents challenges to obtaining valid, informed consent for clinical trials needed to address key clinical questions to improve care.  We propose an innovative strategy to address this.